Satoshi Habuchi

Principal Investigator

Professor

Current

Location:

B2-4277

Social Profile:

Biography

Satoshi Habuchi received his doctorate in chemistry from Hokkaido University. He joined the group of Professor Frans De Schryver and Professor Johan Hofkens as a postdoctoral fellow in KU Leuven in 2001, and studied optical switching of fluorescent proteins at the single molecule level. He joined the group of Professor Antoine van Oijen in Harvard Medical School in 2005 as a post-doctoral fellow, and worked on eukaryotic DNA replication at the single-molecule level as well as optical switching of single molecules and its application to super-resolution fluorescence imaging. Satoshi Habuchi was appointed as Assistant Professor in 2008 and later Associate Professor in 2011 at Tokyo Institute of Technology. He was appointed as Associate Professor in 2012 and later Professor in 2019 at KAUST, Division of Biological and Environmental Science and Engineering.

Selected Publications

  • Shielding Effects Provide a Dominant Mechanism in J-Aggregation-Induced Photoluminescence Enhancement of Carbon Nanotubes              Hubert Piwoński, Kacper Szczepski, Mariusz Jaremko, Łukasz Jaremko, Satoshi Habuchi  ACS Omega 2024, 9, 14, 16496–16507.
  • Self-Assembly of Geometry-Based DNA Origami-Histone Protein Hybrid Nanostructures for Constructing Rationally-Designed Higher-Order Structures    Hajar Al-zarah, Maged F. Serag, Maram Abadi, Satoshi Habuchi             ACS Appl. Nano Mater. 2023, 6, 11, 9515–9522.
  • Nanoscopic Characterization of Cell Migration under Flow Using Optical and Electron Microscopy             abdullah alghamdi, amar tamra, aigerim rakhmatulina, Shuho Nozue, Asma S. Al-Amoodi, Mansour Aldehaiman, ioannis isaioglou, Jasmeen S. Merzaban, Satoshi Habuchi         ACS Anal. Chem. 2023, 95, 3, 1958–1966.
  • The Pursuit of Shortwave Infrared-Emitting Nanoparticles with Bright Fluorescence through Molecular Design and Excited-State Engineering of Molecular Aggregates             Hubert Piwoński, Shuho Nozue, Satoshi Habuchi      ACS Nanosci. Au 2022, 2, 4, 253–283.
  • New article on Organic J-Aggregate nanodots with enhanced light absorption and near-unity fluorescence quantum yield            Hubert Piwoński, Shuho Nozue, Hiroyuki Fujit, Tsuyoshi Michinobu, Satoshi Habuchi            ACS Nano Lett. 2021, 21, 7, 2840–2847.
  • Single-molecule imaging and microfluidic platform reveal molecular mechanisms of leukemic cell rolling      Bader Al Alwan, Karmen AbuZineh, Shuho Nozue, aigerim rakhmatulina, Mansour Aldehaiman, Asma S. Al-Amoodi, Maged F. Serag, Fajr A. Aleisa, Jasmeen S. Merzaban, Satoshi Habuchi             Nature Communication biology 2021, 4, 868.
  • New article on detection of single shortwave-infrared-emitting polymer dots through turbid media            Hubert Piwoński, Wei Li, Yang Wang, Tsuyoshi Michinobu, Satoshi Habuchi            ACS Nano Lett. 2020, 20, 12, 8803–8810.
  • Improved Fluorescence and Brightness of Near-Infrared and Shortwave Infrared Emitting Polymer Dots for Bioimaging Applications          Hubert Piwoński, Wei Li, Yang Wang, Tsuyoshi Michinobu, Satoshi Habuchi        ACS Applied Polymer Materials 2020, 2, 569-577.
  • Geometry-Based Self-Assembly of Histone-DNA Nanostructures at Single-Nucleotide Resolution          Serag M.F., Aikeremu A., Tsukamoto R., Piwoński H., Abadi M., Kaji N., Dwyer J.R., Baba Y., Habuchi S.          ACS Nano 2019, 13, 8155-8168.
  • Entangled Polymer Dynamics Beyond Reptation          Abadi M., Serag M.F., Habuchi S.          Nature Communications 2018, 9, 5098.
  • Microfluidics-Based Super-Resolution Microscopy Enables Nanoscopic Characterization of Blood Stem Cell Rolling          AbuZineh K., Joudeh L.I., Al Alwan B., Hamdan S.M., Merzaban J.S., Habuchi S.          Science Advances 2018, 4, eaat5304.
  • Controlling Photophysical Properties of Ultrasmall Conjugated Polymer Nanoparticles through Polymer Packing       Piwoński H., Michinobu T., Habuchi S.    Nature Communications 2017, 8, 15256
  • Conserved Linear Dynamics of Single-Molecule Brownian Motion          Serag M.F., Habuchi S. Nature Communications 2017, 8, 15675.
  • Single-Molecule Diffusion and Conformational Dynamics by Spatial Integration of Temporal Fluctuations          Serag M.F., Abadi M., Habuchi S.         Nature Communications 2014, 5, 5123.
  • A general Approach to Break the Concentration Barrier in Single-Molecule Imaging          Loveland A.B., Habuchi S., Walter J.C., van Oijen A.M.          Nature Methods 2012, 9, 987-992.
  • Multimode Diffusion of Ring Polymer Molecules Revealed by a Single-Molecule Study          Habuchi S., Satoh N., Yamamoto T., Tezuka Y., Vacha M.          Angew. Chem. Int. Ed. 2010, 49, 1418-1421.
  • mKikGR, a Monomeric Photoswitchable Fluorescent Protein          Habuchi S., Tsutsui H., Kochaniak A.B., Miyawaki A., van Oijen A.M.          PLoS One 2008, 3, e3944.
  • Photoconversion in the Red Fluorescent Protein from the Sea Anemone Entacmaea Quadricolor: Is Cis-Trans Isomerization Involved?          Loos D.C., Habuchi S., Flors C., Hotta J., Wiedenmann J., Nienhaus U., Hofkens J.          J. Am. Chem. Soc. 2006, 128, 6270-6271.
  • Reversible Single-Molecule Photoswitching in the GFP-Like Fluorescent Protein Dronpa          Habuchi S., Ando R., Dedecker P., Verheijen W., Mizuno H., Miyawaki A., Hofkens J.          Proc. Natl. Acad. Sci. U.S.A. 2005, 102, 9511-9516.
  • Evidence for the Isomerization and Decarboxylation in the Photoconversion of the Red Fluorescent Protein DsRed          Habuchi S., Cotlet M., Gensch T., Bednarz T., Haber-Pohlmeier S., Rozenski J., Dirix G., Michiels J., Vanderleyden J., Heberle J., De Schryver F.C., Hofkens J.          J. Am. Chem. Soc. 2005, 127, 8977-8984.
  • Single-Molecule Surface Enhanced Resonance Raman Spectroscopy of the Enhanced Green Fluorescent Protein          Habuchi S., Cotlet M., Gronheid R., Dirix G., Michiels J., Vanderleyden J., De Schryver F.C., Hofkens J.          J. Am. Chem. Soc. 2003, 125, 8446-8447.
  • Identification of Different Emitting Species in the Red Fluorescent Protein DsRed by Means of Ensemble and Single-Molecule Spectroscopy          Cotlet M., Hofkens J., Habuchi S., Dirix G., Van Guyse M., Michiels J., Vanderleyden J., De Schryver F.C.          Proc. Natl. Acad. Sci. U.S.A. 2001, 98, 14398-14403.

Education

  • Ph.D., Chemistry, Hokkaido University, Japan, 2001
  • M.S., Chemistry, Hokkaido University, Japan, 1999
  • B.S., Chemistry, Hokkaido University, Japan, 1997

Professional Profile

  • Professor, KAUST, 2019
  • Associate Professor, KAUST, 2012
  • Associate Professor, Tokyo Institute of Technology, Japan, 2011
  • Assistant Professor, Tokyo Institute of Technology, Japan, 2008
  • Postdoctoral Fellow, Harvard University, USA, 2005
  • Postdoctoral Fellow, The Katholieke Universiteit Leuven (KU Leuven), Belgium, 2001