Satoshi Habuchi

Principal Investigator

Professor

Current

Location:

B2-4277

Social Profile:

Biography

Satoshi Habuchi received his doctorate in chemistry from Hokkaido University. He joined the group of Professor Frans De Schryver and Professor Johan Hofkens as a postdoctoral fellow in KU Leuven in 2001, and studied optical switching of fluorescent proteins at the single molecule level. He joined the group of Professor Antoine van Oijen in Harvard Medical School in 2005 as a post-doctoral fellow, and worked on eukaryotic DNA replication at the single-molecule level as well as optical switching of single molecules and its application to super-resolution fluorescence imaging. Satoshi Habuchi was appointed as Assistant Professor in 2008 and later Associate Professor in 2011 at Tokyo Institute of Technology. He was appointed as Associate Professor in 2012 and later Professor in 2019 at KAUST, Division of Biological and Environmental Science and Engineering.

Selected Publications

  • Geometry-Based Self-Assembly of Histone-DNA Nanostructures at Single-Nucleotide Resolution          Serag M.F., Aikeremu A., Tsukamoto R., Piwoński H., Abadi M., Kaji N., Dwyer J.R., Baba Y., Habuchi S.          ACS Nano 2019, 13, 8155-8168.
  • Entangled Polymer Dynamics Beyond Reptation          Abadi M., Serag M.F., Habuchi S.          Nature Communications 2018, 9, 5098.
  • Microfluidics-Based Super-Resolution Microscopy Enables Nanoscopic Characterization of Blood Stem Cell Rolling          AbuZineh K., Joudeh L.I., Al Alwan B., Hamdan S.M., Merzaban J.S., Habuchi S.          Science Advances 2018, 4, eaat5304.
  • Controlling Photophysical Properties of Ultrasmall Conjugated Polymer Nanoparticles through Polymer Packing          Piwoński H., Michinobu T., Habuchi S.          Nature Communications 2017, 8, 15256
  • Conserved Linear Dynamics of Single-Molecule Brownian Motion          Serag M.F., Habuchi S.          Nature Communications 2017, 8, 15675.
  • Single-Molecule Diffusion and Conformational Dynamics by Spatial Integration of Temporal Fluctuations          Serag M.F., Abadi M., Habuchi S.         Nature Communications 2014, 5, 5123.
  • A general Approach to Break the Concentration Barrier in Single-Molecule Imaging          Loveland A.B., Habuchi S., Walter J.C., van Oijen A.M.          Nature Methods 2012, 9, 987-992.
  • Multimode Diffusion of Ring Polymer Molecules Revealed by a Single-Molecule Study          Habuchi S., Satoh N., Yamamoto T., Tezuka Y., Vacha M.          Angew. Chem. Int. Ed. 2010, 49, 1418-1421.
  • mKikGR, a Monomeric Photoswitchable Fluorescent Protein          Habuchi S., Tsutsui H., Kochaniak A.B., Miyawaki A., van Oijen A.M.          PLoS One 2008, 3, e3944.
  • Photoconversion in the Red Fluorescent Protein from the Sea Anemone Entacmaea Quadricolor: Is Cis-Trans Isomerization Involved?          Loos D.C., Habuchi S., Flors C., Hotta J., Wiedenmann J., Nienhaus U., Hofkens J.          J. Am. Chem. Soc. 2006, 128, 6270-6271.
  • Reversible Single-Molecule Photoswitching in the GFP-Like Fluorescent Protein Dronpa          Habuchi S., Ando R., Dedecker P., Verheijen W., Mizuno H., Miyawaki A., Hofkens J.          Proc. Natl. Acad. Sci. U.S.A. 2005, 102, 9511-9516.
  • Evidence for the Isomerization and Decarboxylation in the Photoconversion of the Red Fluorescent Protein DsRed          Habuchi S., Cotlet M., Gensch T., Bednarz T., Haber-Pohlmeier S., Rozenski J., Dirix G., Michiels J., Vanderleyden J., Heberle J., De Schryver F.C., Hofkens J.          J. Am. Chem. Soc. 2005, 127, 8977-8984.
  • Single-Molecule Surface Enhanced Resonance Raman Spectroscopy of the Enhanced Green Fluorescent Protein          Habuchi S., Cotlet M., Gronheid R., Dirix G., Michiels J., Vanderleyden J., De Schryver F.C., Hofkens J.          J. Am. Chem. Soc. 2003, 125, 8446-8447.
  • Identification of Different Emitting Species in the Red Fluorescent Protein DsRed by Means of Ensemble and Single-Molecule Spectroscopy          Cotlet M., Hofkens J., Habuchi S., Dirix G., Van Guyse M., Michiels J., Vanderleyden J., De Schryver F.C.          Proc. Natl. Acad. Sci. U.S.A. 2001, 98, 14398-14403.

Education

  • Ph.D., Chemistry, Hokkaido University, Japan, 2001
  • M.S., Chemistry, Hokkaido University, Japan, 1999
  • B.S., Chemistry, Hokkaido University, Japan, 1997

Professional Profile

  • Professor, KAUST, 2019
  • Associate Professor, KAUST, 2012
  • Associate Professor, Tokyo Institute of Technology, Japan, 2011
  • Assistant Professor, Tokyo Institute of Technology, Japan, 2008
  • Postdoctoral Fellow, Harvard University, USA, 2005
  • Postdoctoral Fellow, The Katholieke Universiteit Leuven (KU Leuven), Belgium, 2001